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• MAC + PRA1 doubletest for Schnauzer Miniature for better price
• MC + MAC doubletest for Schnauzer Miniature for better price

Mycobacterium avium complex (MAC) is a group of mycobacteria that contains potentially pathogenic organisms. The MAC includes Mycobacterium avium and Mycobacterium intracellulare. These organisms are commonly present in the environment – in soil, water and air. Therefore, dogs are often exposed to this pathogen, however usually they are not at risk because dogs posses natural resistance to infection with MAC. But in susceptible patients these organisms are capable of producing generalized disease due to a defect in the immune system. It has been proven the importance of genetic factors in determining both susceptibility to infection and whether or not there is subsequent development of clinical disease.

The MAC infection is a life threatening disease. The primary sign is lymph node enlargement as well as liver and spleen enlargement. The affected dog is lethargic and shows further symptoms such as vomiting, anorexia, weakness and fever. The dogs may also suffer from runny nose, conjunctivitis, diarrhoea, blood in stool or respiratory problems. The infection is incurable and always fatal.

The genetic disorder causing susceptibility to MAC infections has been discovered in Miniature Schnauzer. All these affected dogs were related to a particular dog under suspicion of being a genetic source for the potential immune system defect allowing a MAC infection. The most cases were diagnosed in the USA and Canada, but some cases were reported from Poland and other parts of Europe. The occurrence of polymorphism carriers is approximately 10% in Europe and North America.

The polymorphism is recessively inherited. The increased susceptibility to MAC develops in dogs which inherit the variant gene from each parent. These dogs are designated as P/P (positive/positive). The carriers of the polymorphism are designated as N/P (negative/positive). The carriers inherited the variant gene from one parent only and are without clinical signs. However, they pass the disease on to their offspring. When mating two heterozygotes (N/P), there will be theoretically 25% of the offspring healthy, 50% of the offspring will be carriers and 25% of the offspring will inherit the polymorphism from both parents and will be in risk of MAC. Mating one healthy dog (N/N) with a carrier of this polymorphism (N/P) will theoretically produce 50% carriers and 50% healthy offspring. If a carrier (N/P) is mated with an affected dog (P/P), there will be theoretically 50% affected dogs and 50% carriers.

The increased susceptibility to pathogenic organisms M.avium and M. intracellulare is caused by gene variant in CARD9-gene that has an important regulatory function in cell apoptosis and plays an important role in natural immune response to pathogens such as, for example, yeasts.

MAC is potentially infectious for humans. The health of people is not at risk, because humans generally have the same innate immunity to this pathogen as dogs. However, persons with HIV/AIDS, diabetes, cancer or other immune system disorders should consult with their doctor if they have dog diagnosed with MAC.

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Reference:

Errolyn Martin: Disseminated Mycobacterium Avium Complex Infection in Miniature Schnauzers

Keijiro Mizukami, Angella Dorsey-Oresto, Karthik Raj, Anna Erings, Eva Furrow, Gary S. Johnsom, Urs Giger: A codon deletion in CARD9 gene causes increased susceptibility to Mycobacterium Avium complex in Miniature Schnauzer Dogs: The 9th international conference on canine and feline genetics and genomics

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After you download TestNav Desktop and ProctorCache, complete the following:

These ordered steps correspond to sections below or a related setup page. You can click each link to go directly to the corresponding processes.

1. Install TestNav Desktopusing the instructions below.

2. Run App Checkto verify system readiness.
3. Sign in to TestNavto ensure that it installed properly.

4. Set up ProctorCacheon proctor caching computer(s).

5. Set Up Response File Backups, and set up a Secondary Save Location.

6. Run an infrastructure trial.

Install TestNav Desktop

TestNav program files are saved in Applications/TestNav.

1. Double-click the .dmg file (for example, testnav-1.4.1.dmg) that youdownloaded. The TestNav install window appears.
   

2. Drag the TestNav icon into the Applications folder.

3. Eject the TestNav installer from Devices in the Finder sidebar. You can also eject it from the Desktop.
   

Mass Install

You can copy the TestNav application and push it to student computers for mass installation.

For macOS 10.14+, you must grant TestNav full privacy & accessibility control to administer secure tests. Click or tap System Preferences > Security& Privacy > Privacy. Scroll to Accessibility, and add or select TestNav.

• Disable Siri and/or Dictation services before attempting to sign in to TestNav.

• If you use computer restoration or imaging software (for example, Deep Freeze), exclude the Pearson directory and the logs directory, as these contain student backup files and logs for troubleshooting.

TestNav Desktop Updates

TestNav program file updates are saved in {user_home}/Library/Application Support/Pearson. You must give students write access to the update directory.

• Any necessary patch updates automatically install whenever TestNav starts or when a student attempts to log in. This ensures the update is implemented even if schools leave TestNav running over the course of a few days.
  You can also push the latest TestNav update, rather than waiting until each student opens TestNav. To push an update, take a snapshot of the Pearson folder, and push that folder to all student computers.
• Updates that require reinstallation are scheduled for winter and summer breaks.
• Pearson will communicate all updates with instructions in advance.

When you install TestNav Desktop, it creates the TestNav folder within the Pearson folder shown in the path above. The TestNav folder contains the following:

• The update file folder, named with the update version number (for example, 1.4.1)
• The default file, which stores the customer login preference for the next login

The login preference stored in the default file can change if you select a different customer from the Sign In page. You can set the default file to read-only to prevent students from overwriting it after you set your test preference.

If you encounter any issues during an update, you can find the errorlog folder within the update folder (for example: 1.4.1 > update > errorlog). The errorlog folder logs any issues TestNav may encounter when it attempts an update. You can also delete the Pearson folder to reset TestNav, clearing out any updates stored in that directory.

Run App Check

To run App Check:

1. Click or tap the appropriate icon for your test from the home page to go to the Sign In page.

2. Click or tap the user drop-down menu, and select App Check.

App Check (without optional Configuration Identifier)

On the App Check page:

1. Leave the configuration identifier field blank.

2. Click Run App Check.

You see green checkboxes for Kiosk Mode readiness and connectivity to TestNav, if the system passes. If one of these fails, you will see a Fail message and must check your connection and settings before running App Check again.

App Check (with optional Configuration Identifier)

If you have obtained a Configuration Identifier from your assessment management system:

1. Enter it in the Configuration Identifier field on the App Check page.

   The configuration identifier allows TestNav to also check connection to ProctorCache computers. If your assessment management system allows, this configuration ID may also check for blacklist compliance. See your assessment management system documentation for additional information.

2. Click Run App Check.

3. If ProctorCache connectivity (or blacklist compliance) fail, TestNav provides information for possible resolutions. Use this information to troubleshoot, and run App Check again.
   The screenshots below are examples of possible scenarios when running App Check with a configuration identifier.

   ProctorCache Pass

   ProctorCache Fail

   Blacklist Pass

   Blacklist Fail

Sign in to TestNav

1. Open TestNav from the Applications folder.

2. If you have not already done so, choose the appropriate icon for your test on the home page. If your test was selected before the test session, you see the Sign In page, rather than the home page.

   1. If you need to select a different test, click the user drop-down menu at the upper-right of the page, and click Choose a different customer.
      

   2. Click the appropriate icon for your test.
      

3. Start a test to ensure that you can do so without error.

• • If you see a Practice Tests link on the Sign in page, click Practice Tests and start a test.
  • If you do not see a Practice Tests link, use an authorization ticket from your student management system and start a test.

Set Up Response File Backups

TestNav has a default primary SRF save location for all computers and devices. Pearson strongly recommends setting a secondary save location for SRFs as a backup. For detailed information on saved response files (SRFs) and log files, see

Test Generator For Mac

Understand SRFs and Log Files for Installable TestNav.

SFTP configuration is not supported by all assessment management systems. Consult your assessment management system user guide to determine whether the SFTP option is available.

Before testing, refer to your assessment management system user guide to configure TestNav and complete the following steps.

1. Configure primary and a secondary save location through your assessment management system.

2. Configure student accounts to have complete read, write, and delete access in these save locations.

3. Communicate SRF and log file locations to test proctors.

4. Give proctors access to SRF and log files by either of the following:

   • Grant admin rights to proctors on each testing computer.
     

   • Instruct proctors to access these files while the student is logged in to the testing computer.

Default Primary Save Location

Pearson Testgen 7.4

Operating System	SRF Location	Log File Location
OS X	{USER_HOME}/Pearson/srf/	{USER_HOME}/Pearson/logs/

Pearson strongly recommends that you configure a network drive as a secondary save location to ensure that you do not lose responses, even if a student cannot continue to test on the same computer.

Secondary Save Location

You can set a secondary save location through your assessment management system. Set a secure file transfer protocol (SFTP) address as the save location to ensure that the secondary save applies to all testing computers and devices.

Run an Infrastructure Trial

Pearson strongly recommends running an infrastructure trial to verify the technology setup is complete and to familiarize teachers and students with the test.

Use your training site through your assessment management system to complete the trial before the actual test day.

Related Information

You can learn more about SRF and log files on theSet up and Use TestNavpage.